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KMID : 1103920120180020225
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Korean Journal of Hepatology
2012 Volume.18 No. 2 p.225 ~ p.228
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A fatal case of hepatitis B virus (HBV) reactivation during long-term, very-low-dose steroid treatment in an inactive HBV carrier
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Bae Joong-Ho
Sohn Joo-Hyun
Lee Hye-Soon
Park Hye-Sun
Hyun Yil-Sik
Kim Tae-Yeob
Eun Chang-Soo
Jeon Yong-Cheol
Han Dong-Soo
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Abstract
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Hepatitis B virus (HBV) may be reactivated after chemotherapy or immunosuppressive therapy, and therefore administration of antiviral agents before such treatment is recommended. Most reported cases of reactivation are associated with high doses of immunosuppressive agents or combination therapy. We present a case of a previously inactive HBV carrier with an acute severe flare-up during a long-term, very-low-dose (2.5 mg/day) steroid treatment for rheumatoid arthritis. We suggest that even a minimal dose of single-regimen oral steroid can cause reactivation of indolent, inactive HBV.
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KEYWORD
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Hepatitis B virus, Liver failure, Steroids, Virus activation
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